Cardiovascular
Case TypeClinical Cases
Authors
Eduardo González-Cárdenas, Pilar Olmedilla Arregui, Pablo Robles Velasco
Patient26 years, male
A 26-year-old man with no remarkable past medical history presented to the Emergency Department with a 24-hour history of left parasternal chest pain. No fever, cough or dyspnea. EKG was normal but blood work showed elevated troponin and C-reactive protein values. Echocardiography was performed and showed hypokinetic movement of the lateral wall. He was then referred for cardiac magnetic resonance (CMR) imaging. The patient had received immunization for COVID (Moderna) 3 weeks prior to the event.
CMR showed normal biventricular volumes with preserved systolic function. Normal left ventricular mass and wall thickness with mild hypokinesia of mid anterior segment.
T2-mapping showed increased T2 relaxation time in keeping with myocardial oedema affecting basal and mid anterior segments. There was no evidence of hypoperfusion.
Estimated extracellular volume was 30%.
On viability series there was late gadolinium subepicardial enhancement in basal inferoseptal, anterolateral and inferolateral segments, as well as midwall enhancement in mid inferior segment.
There was no evidence of pericardial effusion.
These findings are consistent with acute myocarditis. Most common causes of myocarditis were clinically excluded: there was no evidence of systemic infection and the patient had no history of immunological disorder or recent drug use.
Functional parameters of the left ventricle (body mass-indexed values in parenthesis):
- End-diastolic volume (EDV) 149 ml (78 ml/m²). Normal values (NV) for male patients aged 20-29: 126-208 ml
- End-systolic volume (ESV) 57 ml (30 ml/m²). NV: 35-80 ml
- Systolic volume (SV) 92 ml (48 ml/m²). NV: 81-137 ml
- Ejection fraction (EF) 62%. NV: 57-74%
- Cardiac output 6.5 l/min (3.3 l/(min*m²)). NV: 4-8 l/min
- Myocardial mass 93 g. NV: 109-186 g
Functional parameters of the right ventricle:
- EDV 116 ml (61 ml/m²). NV: 127-227 ml
- ESV 36 ml (19 ml/m²). NV: 38-98 ml
- SV 80 ml (42 ml/m²). NV: 74-143 ml
- EF 60%. NV: 48-74%
Myocarditis is defined as the nonischemic inflammation of the myocardium.
Many triggers have been described in its pathogenesis, although most cases in developed countries are attributable to viral infection.
Symptoms are nonspecific and can mimic myocardial infarction [1], typically affecting young male patients, and it has been estimated that it may be responsible for 20% of deaths in adults younger than 40 years of age [2].
Although rare, immunization can also cause myocarditis and there is recent evidence that COVID-19 vaccination can increase the risk, particularly after the second booster of mRNA vaccines by cross-reaction mechanism [3], [4], [5].
Myocarditis is often clinically suspected by exclusion of other entities, and endomyocardial biopsy is only recommended in selected number of cases [6], [7].
Evaluation and management of these patients vary depending on clinical factors although most patients can be managed medically [8].
CMR has become the imaging modality of choice in patients with suspected acute nonischemic cardiomyopathy [9].
MR findings are commonly assessed using the Lake Louise criteria (LLC) [10]. To make the diagnosis, high clinical pretest probability is required, as well as a T2-based marker of myocardial oedema and a T1-based marker of myocardial damage [11].
Findings include:
In this case, there is evidence of myocardial oedema (T2-based marker) and of myocardial damage in the form of late gadolinium enhancement (T1-based marker).
Most recent studies show that myocardial inflammation secondary to COVID-19 vaccination may have milder MR abnormalities as compared to other causes of myocarditis [15].
CMR in myocarditis can provide valuable prognostic data and guide the decision-making process in terms of therapeutic options. Furthermore, in around 11% of cases, it provides an alternative diagnosis [16].
Take-Home Message / Teaching Points
There is evidence that COVID-19 vaccination can induce acute myocardial inflammation, especially after the second booster of mRNA vaccines and most commonly in young males.
CMR is the diagnostic modality of choice for its assessment due to its capability to noninvasively detect and quantify myocardial alterations like oedema, hyperemia, scarring or necrosis as well as wall motion abnormalities or ventricular dysfunction in more severe cases.
Written informed patient consent for publication has been obtained.
[1] G. Sinagra et al., “Myocarditis in Clinical Practice,” Mayo Clinic Proceedings, vol. 91, no. 9. Elsevier Ltd, pp. 1256–1266, Sep. 01, 2016. doi: 10.1016/j.mayocp.2016.05.013.
[2] Y. Drory et al., “Sudden unexpected death in persons less than 40 years of age,” The American Journal of Cardiology, vol. 68, no. 13, pp. 1388–1392, Nov. 1991, doi: 10.1016/0002-9149(91)90251-F.
[3] A. Husby et al., “SARS-CoV-2 vaccination and myocarditis or myopericarditis: Population based cohort study,” The BMJ, vol. 375, Dec. 2021, doi: 10.1136/bmj-2021-068665.
[4] G. Witberg et al., “Myocarditis after Covid-19 Vaccination in a Large Health Care Organization,” New England Journal of Medicine, vol. 385, no. 23, pp. 2132–2139, Dec. 2021, doi: 10.1056/nejmoa2110737.
[5] S. Heymans and L. T. Cooper, “Myocarditis after COVID-19 mRNA vaccination: clinical observations and potential mechanisms,” Nature Reviews Cardiology, vol. 19, no. 2. Nature Research, pp. 75–77, Feb. 01, 2022. doi: 10.1038/s41569-021-00662-w.
[6] L. T. Cooper et al., “The role of endomyocardial biopsy in the management of cardiovascular disease: A Scientific Statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology Endorsed by the Heart Failure Society of America and the Heart Failure Association of the European Society of Cardiology,” European Heart Journal, vol. 28, no. 24, pp. 3076–3093, Nov. 2007, doi: 10.1093/eurheartj/ehm456.
[7] F. Dominguez, U. Kühl, B. Pieske, P. Garcia-Pavia, and C. Tschöpe, “Actualización sobre miocarditis y miocardiopatía inflamatoria: el resurgir de la biopsia endomiocárdica,” Revista Española de Cardiología, vol. 69, no. 2, pp. 178–187, Feb. 2016, doi: 10.1016/j.recesp.2015.10.018.
[8] B. Bozkurt, I. Kamat, and P. J. Hotez, “Myocarditis With COVID-19 mRNA Vaccines,” Circulation, vol. 144, no. 6, pp. 471–484, Aug. 2021, doi: 10.1161/CIRCULATIONAHA.121.056135.
[9] M. G. Friedrich and F. Marcotte, “Cardiac magnetic resonance assessment of myocarditis,” Circulation: Cardiovascular Imaging, vol. 6, no. 5, pp. 833–839, Sep. 2013, doi: 10.1161/CIRCIMAGING.113.000416.
[10] V. M. Ferreira et al., “Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation: Expert Recommendations,” Journal of the American College of Cardiology, vol. 72, no. 24, pp. 3158–3176, Dec. 2018, doi: 10.1016/j.jacc.2018.09.072.
[11] F. S. Tijmes, P. Thavendiranathan, J. A. Udell, M. Seidman, and K. Hanneman, “Cardiac mri assessment of nonischemic myocardial inflammation: State of the art review and update on myocarditis associated with covid-19 vaccination,” Radiology: Cardiothoracic Imaging, vol. 3, no. 6, 2021, doi: 10.1148/ryct.210252.
[12] M. G. Friedrich et al., “Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper,” Journal of the American College of Cardiology, vol. 53, no. 17. pp. 1475–1487, Apr. 28, 2009. doi: 10.1016/j.jacc.2009.02.007.
[13] J. A. Luetkens et al., “Acute myocarditis: Multiparametric cardiac MR imaging,” Radiology, vol. 273, no. 2, pp. 383–392, Nov. 2014, doi: 10.1148/radiol.14132540.
[14] G. C. W. Chu, J. A. Flewitt, Y. Mikami, E. Vermes, and M. G. Friedrich, “Assessment of acute myocarditis by cardiovascular MR: diagnostic performance of shortened protocols,” The International Journal of Cardiovascular Imaging, vol. 29, no. 5, pp. 1077–1083, Jun. 2013, doi: 10.1007/s10554-013-0189-7.
[15] M. Fronza et al., “Myocardial Injury Pattern at MRI in COVID-19 Vaccine–associated Myocarditis,” Radiology, Feb. 2022, doi: 10.1148/radiol.212559.
[16] O. Bruder et al., “European cardiovascular magnetic resonance (EuroCMR) registry – multi national results from 57 centers in 15 countries,” Journal of Cardiovascular Magnetic Resonance, vol. 15, no. 1, p. 9, Dec. 2013, doi: 10.1186/1532-429X-15-9.
URL: | https://www.eurorad.org/case/17698 |
DOI: | 10.35100/eurorad/case.17698 |
ISSN: | 1563-4086 |
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.