CASE 17590 Published on 17.01.2022

Testicular adrenal rest tumors


Uroradiology & genital male imaging

Case Type

Clinical Cases


Eduardo Bandeira1, Rita Cabrita Carneiro2, Eugénia Soares2

1. Department of Radiology, Centro Hospitalar de Lisboa Ocidental, Estrada do Forte do Alto do Duque, 1449-005 Lisbon, Portugal.

2. Department of Radiology, Hospital Dona Estefânia, Centro Hospitalar e Universitário de Lisboa Central, Rua Jacinta Marto, 1169-045 Lisbon, Portugal.


12 years, male

Area of Interest Genital / Reproductive system male, Paediatric ; Imaging Technique Ultrasound, Ultrasound-Colour Doppler
Clinical History

A 12-year-old male patient with the neonatal diagnosis of congenital adrenal hyperplasia presented to our institution with a 6-hour history of acute scrotal pain after a minor blunt trauma during rugby practice. The patient denied nausea or vomiting. Physical examination was normal.

Imaging Findings

Scrotal ultrasound assessment was performed and no signs of testicular or epididymis fracture, testicular or scrotal wall hematoma were present. Signs of haematocele were also absent.

Ultrasound revealed one round and homogeneously hypoechoic nodule in each testicle. Both nodules, measuring 6 mm and 4 mm, were adjacent to the mediastinum testis. They were hypervascular on colour Doppler imaging.


Serum testicular tumor markers (alpha-fetoprotein, beta human chorionic gonadotropin and lactate dehydrogenase) were not elevated. Given the known history of congenital adrenal hyperplasia (CAH), the bilateral findings and the lesions characteristics and location, the diagnosis of testicular adrenal rest tumors (TARTs) was considered likely.

CAH refers to a group of autosomal recessive disorders in steroid and glucocorticoid synthesis secondary to an enzymatic deficiency. In over 90% cases, the deficient enzyme is 21-hydroxylase, while in other cases the deficient enzyme is 11-hydroxylase [1]. The impaired production of cortisol and aldosterone leads to overproduction of adrenocorticotropic hormone (ACTH), adrenal hyperplasia, and excess adrenal androgen production [2].

Male patients with CAH may develop TARTs, with an increasing prevalence rate observed during and after puberty [1]. The etiology of these benign lesions is unclear, but possibilities include adrenal rests and pluripotent ectopic adrenal cortex remnant cells of the testicular stroma which differentiate and grow under the influence of chronically elevated ACTH [2].

TARTs are usually asymptomatic but can grow in size, compress and replace normal testicular parenchyma, leading to disorders in spermatogenesis and infertility [2].

Ultrasonography is considered to be the first-line imaging modality for detection, characterization and follow-up of TARTs [2]. Ultrasound imaging features are multiple, bilateral and well-marginated masses located along the mediastinum testis. These masses are more frequently hypoechoic, but they can be heterogeneously hyperechoic with shadowing [3]. Most of the lesions have positive colour flow on Doppler imaging [4]. Some of these ultrasound features can overlap with other testicular lesions. The main differential diagnostic considerations for TARTs are malignancy (both primary and metastatic disease), infection, and sarcoidosis [2]. The great majority of patients with TARTs will have bilateral testicular involvement, whereas other similar appearing entities including Leydig cell tumours will almost always have unilateral involvement [2, 5].

Exogenous glucocorticoids are used for CAH and TART treatment by suppressing ACTH production [1]. Shrinkage or disappearance of TARTs can be seen after steroid therapy [1].

The recognition of this benign entity in the adequate clinical context will help prevent unnecessary orchiectomies.

In our case, one year after the diagnosis, the patient is asymptomatic and the size and number of lesions remain stable at follow-up ultrasound.

Written informed patient consent for publication has been obtained.

Differential Diagnosis List
Testicular adrenal rest tumors
Leydig cell tumours
Metastatic disease
Final Diagnosis
Testicular adrenal rest tumors
Case information
DOI: 10.35100/eurorad/case.17590
ISSN: 1563-4086