CASE 17245 Published on 08.04.2021

Evaluation of a painless palpable mass of the left hemiscrotum with sonography and routine intraoperative frozen section biopsy


Uroradiology & genital male imaging

Case Type

Clinical Cases


Chiara F. Rosa1, Luca Valle2

1. Section of Computed Tomography, Department of Emergency Radiology  IRCCS San Martino, University Hospital, Genoa, Italy

2. Unit of Anatomic Pathology, Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy


30 years, male

Area of Interest Genital / Reproductive system male ; Imaging Technique Ultrasound-Colour Doppler
Clinical History

A 39-year-old man discovered a painless palpable mass in the left hemiscrotum during self-palpatory examination. He had no history of epididymitis, torsion, or trauma. The patient's alpha-fetoprotein, beta-human chorionic gonadotropin and lactate dehydrogenase levels were normal and a sonographic evaluation was consequently performed.

Imaging Findings

Axial and longitudinal ultrasound grey images showed the presence of a small hyperechoic nodule in the lower pole of the left hemiscrotum (DT=7mm); no hydrocele was seen (fig. 1- fig.2). The colour Doppler evaluation showed peripheral, low vascularity (fig. 3) of the nodule. After that the patient was placed in a semi-recumbent position: this  ‘manoeuvre’ performed at sonography showed a hypoechoic line as a separation between the nodule and the parenchyma of the testis, so the paratesticular origin of the nodule. The echogenic area-distance between the epidermis and the tail of the epididymis was also shown to demonstrate the separation between the nodule, the epidermis and the epididymis (fig.4).  Surgical exploration with a routine intraoperative frozen section biopsy showed the presence of adenomatoid tumour of the tunica albuginea testis. This tumour was confirmed after local excision and pathological examination of the specimen (fig. 5-fig.6). Patient showed no signs of recurrence.


Adenomatoid tumour, the second most common benign tumour of the paratestis after lipoma, accounts for approximately 30% of all paratesticular neoplasms. The great majority of these tumours in men are found in the epididymis  (about 77%), the testis sheath or tunica albuginea (about 22%), with only rare case reports in the spermatic cord (about 1%) from the seminal vesicle [2]. The tumours are smooth, round, and well-circumscribed and can vary in size from a few millimetres up to 5 cm. They are believed to be of mesothelial origin and are universally benign [2].

Clinical Perspective

It is a substantial clinical very rare tumour and it typically presents as a hard painless mass discovered incidentally on physical examination of the scrotum in men between the third and seventh decades, and more common of 30-40 years old.

Imaging Perspective

Sonography is the primary imaging method used to evaluate the origin of a scrotal mass. On sonographic scans, they typically appear hyperechoic and homogeneous. This appearance should not, however, be considered characteristic because great variability in sonographic findings has been reported. If the lesion is confined to the epididymis, the differentiation can easily be made.  However, if the lesion is originating from the tunics of the testis, the differentiation can be troublesome. As a matter of fact, if the tumour arises from the lamina parietalis of the tunica vaginalis, sonographic differentiation is possible when sufficient fluid accumulation separates the layers of the tunica vaginalis, but it is not possible when the tumour arises from the lamina visceralis of the tunica vaginalis or the tunica albuginea [3]. Additional ultrasound images performed after the ‘manoeuvre mentioned’, MRI and CT evaluation if necessary, may provide morphologic evidence to allow precise localisation of the origin of the mass and may also show typical features that enable further confidence of a benign diagnosis [4].

Outcome and teaching points

Therefore, scrotal exploration and histological examination can be regarded as mandatory; it is also recommended routine intraoperative frozen section biopsy as it may allow for testicular preservation.

Differential Diagnosis List
Adenomatoid tumor of the tunica albuginea testis
Leiomyoma is the second most common benign tumour of the epididymis
Lipoma is a benign tumour composed of mature adipocytes
Cystoadenoma is a tumour with a strong association with von Hippel – Lindau disease.
Fibrous pseudotumor is a benign fibroinflammatory reaction
Final Diagnosis
Adenomatoid tumor of the tunica albuginea testis
Case information
DOI: 10.35100/eurorad/case.17245
ISSN: 1563-4086