Chest imaging
Case TypeClinical Cases
Authors
Claudio Sicuso1, Luca Balzarini2, Romano Fabio Lutman3, Manuel Profili3, Ezio Lanza4, Letterio Salvatore Politi5
Patient72 years, female
A 72-year-old female patient with a history of ischaemic stroke, ocular myasthenia, arterial hyper-tension, and hypercholesterolaemia was admitted to the emergency department because of dyspnoea.
She reported having fever and cough for a week.
At admission, her pulse oximeter saturation was 84%, the tympanic temperature was 37.6 °C.
Laboratory findings revealed elevated C-reactive protein (19.69 mg/dL, normal range 0.01-0.5 mg/dL) and mild lymphopenia (0.7X10^3/mm^3, normal range 1.0-4.0 X10^3/mm^3).
The patient also underwent non-contrast chest CT.
The non-contrast chest CT performed at admission (Fig. 1) showed bilateral, symmetrical, sub-pleural ground-glass opacities (GGO), predominantly in the right lower lobe, with initial interlobular septal thickening (crazy-paving pattern).
There was no radiological evidence of pleural effusion or mediastinal lymphadenopathy.
These findings were highly suspicious for SARS-CoV-2 infection.
AP chest X-ray (Fig. 2) on day two from admission showed interval intubation, internal jugular vein CVC, nasogastric tube, and bilateral patchy airspace opacities.
A new chest CT scan (Figs. 3-5) was performed on day three of admission, in both supine and prone positions during mechanical ventilation.
Compared to the prior CT, the supine scan showed a significant increase in the extent and atten-uation of the opacities with pulmonary consolidation and atelectasis of the right lower lobe.
The prone scan showed a partial recovery of the aerated lung parenchyma in the right inferior lobe with a small area of residual consolidation in the posterior segment of the right lower lobe.
Background
COVID-19 is an infectious disease that causes mild symptoms in most people; however, some patients, especially those who have comorbidities and the elderly, can progress to pneumonia and acute respiratory distress syndrome (ARDS) [1,2].
Nevertheless, also healthy and young people can develop a severe illness as it happened in Northern Italy with ‘“patient 1’, a man in his 30s [3].
Clinical Perspective
Most patients affected by COVID-19 present primarily with fever, myalgia or fatigue, and
dry cough [1], others may not have clinical symptoms nor radiological abnormalities at presenta-tion [4].
At present, the RT-PCR test is the gold standard for the final diagnosis of COVID-19 [5], even if it is burdened by a false negative rate.
Patients who progress to ARDS and multi-organ failure could benefit from methylprednisolone to decrease the risk of death [6].
In patients with severe ARDS, prone ventilation has been demonstrated to improve oxygenation and respiratory compliance compared to supine positioning [7].
Imaging Perspective
Chest CT scan could be useful for diagnosis of COVID-19 in highly suspected patients, but it should not be used for screening or early diagnosis because of its low specificity that does not allow differentiation between COVID-19 pneumonia and other cases of infection [8].
Chest CT has a role in the follow-up of patients until complete recovery [9].
Patients who develop respiratory deterioration and instability can benefit from lung ultrasonogra-phy that is more sensitive than chest X-ray for evaluation of pneumonia and
ARDS [10].
CT scan in supine and prone position allows to investigate the modification in lung morphology with changes in body position, and leads to a description in vivo of the lung pathology in ARDS.
Outcome
Since admission, the patient was given antiviral treatment based on lopinavir/ritonavir. Due to the rapidity of respiratory deterioration, she however was transferred to the intensive care unit where she underwent invasive mechanical ventilation.
Meanwhile, laboratory testing for SARS-CoV-2 returned positive.
The patient is currently in the intensive care unit and her clinical condition is stable.
Take-home Message
Patients that develop ARDS require a big effort to adjust the ventilatory strategy. [11]
The chest CT has a great impact on therapeutic strategy since it allows to guide response to a prone position and for making decisions related to weaning the patient form ventilatory support.
The addition of a prone scan may be useful to identify the most efficacious strategy for the venti-lation of these patients.
Written informed patient consent for publication has been obtained.
[1] Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., Xiao, Y., … Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wu-han, China. Lancet (London, England), 395(10223), 497–506 (PMID: 31986264)
[2] Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., Yu, T., Zhang, X., & Zhang, L. (2020). Epidemiological and clinical characteris-tics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet (London, England), 395(10223), 507–513 (PMID: 32007143)
[3] Grasselli, G., Pesenti, A., & Cecconi, M. (2020). Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Re-sponse. JAMA, 10.1001/jama.2020.4031 (PMID: 32167538)
[4] Ling, Z., Xu, X., Gan, Q., Zhang, L., Luo, L., Tang, X., & Liu, J. (2020). Asymptomatic SARS-CoV-2 infected patients with persistent negative CT findings. European journal of radiology, 126, 108956 (PMID: 32199142)
[5] Yang, W., & Yan, F. (2020). Patients with RT-PCR Confirmed COVID-19 and Normal Chest CT. Radiology, 200702 (PMID: 32142398)
[6] Wu, C., Chen, X., Cai, Y., Xia, J., Zhou, X., Xu, S., Huang, H., Zhang, L., Zhou, X., Du, C., Zhang, Y., Song, J., Wang, S., Chao, Y., Yang, Z., Xu, J., Zhou, X., Chen, D., Xiong, W., Xu, L., … Song, Y. (2020). Risk Factors Associated With Acute Respiratory Distress Syn-drome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, Chi-na. JAMA internal medicine, e200994 (PMID: 32167524)
[7] Munshi, L., Del Sorbo, L., Adhikari, N., Hodgson, C. L., Wunsch, H., Meade, M. O., Ule-ryk, E., Mancebo, J., Pesenti, A., Ranieri, V. M., & Fan, E. (2017). Prone Position for Acute Respiratory Distress Syndrome. A Systematic Review and Meta-Analysis. Annals of the American Thoracic Society, 14(Supplement_4), S280–S288 (PMID: 29068269)
[8] Hope, M. D., Raptis, C. A., Shah, A., Hammer, M. M., Henry, T. S., & six signatories (2020). A role for CT in COVID-19? What data really tell us so far. Lancet (London, En-gland), S0140-6736(20)30728-5 (PMID: 32224299)
[9] Pan, F., Ye, T., Sun, P., Gui, S., Liang, B., Li, L., Zheng, D., Wang, J., Hesketh, R. L., Yang, L., & Zheng, C. (2020). Time Course of Lung Changes On Chest CT During Re-covery From 2019 Novel Coronavirus (COVID-19) Pneumonia. Radiology, 200370 (PMID: 32053470)
[10] Peng, Q. Y., Wang, X. T., Zhang, L. N., & Chinese Critical Care Ultrasound Study Group (CCUSG) (2020). Findings of lung ultrasonography of novel coronavirus pneumonia dur-ing the 2019-2020 epidemic. Intensive care medicine, 10.1007/s00134-020-05996-6 (PMID: 32166346)
[11] Rouby, J. J., Puybasset, L., Nieszkowska, A., & Lu, Q. (2003). Acute respiratory distress syndrome: lessons from computed tomography of the whole lung. Critical care medicine, 31(4 Suppl), S285–S295 (PMID: 12682454)
URL: | https://www.eurorad.org/case/16673 |
DOI: | 10.35100/eurorad/case.16673 |
ISSN: | 1563-4086 |
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.