Neuroradiology
Case TypeClinical Cases
Authors
Dr. Rahul H. Sharma, Dr. Mrunali M. Shah
Patient27 years, male
A 27-year-old male patient with history of a dog bite on the face presented with altered sensorium and incomprehensible speech since 15 days.
MRI brain (plain study) revealed bilateral symmetrical hyperintensities involving basal ganglion, thalami, splenium of corpus callosum, dorsal aspect of medulla, dentate nuclei of cerebellum and tegmentum of midbrain and pons on T2-and FLAIR-weighted images. These areas appear hypointense on T1W images.
DWI does not reveal any restricted diffusion in the above-mentioned affected areas.
Screening study of spinal cord revealed long intramedullary hyperintense signal-intensity involving cervical spinal cord extending from cervico-medullary junction to C7 vertebral level.
Rabies is considered one of the most fulminant diseases, imaging diagnosis is hardly possible. Rabies is spread by the RNA virus of the Rhabdovirus family, transmitted by the bite of a dog or other wild animals.
Although definite diagnosis requires separation of virus antigen or antibody from biological samples, early management and narrowing the list of differentials of rabies encephalitic may rely upon clinical and imaging evaluation.
Patient with history of dog bite on or in proximity of face usually presents with sudden deterioration after 5-10 days of prodromal symptoms and exhibits phobic spasms, hydro/aerophobia triggered by puffs or sound of air as the hallmark of the disease. [1]
Higher tendency for rabies virus for cerebral gray matter causes involvement of neurons and neuroglial cells with further spread leading to progressive encephalitis. Encephalitic form of rabies predominantly affects the brainstem and cerebrum with further involvement of the basal ganglia and thalami occurring later during the disease – affected initially in paralytic form of the disease [2].
Bilateral symmetric, hypodense lesions without significant enhancement of basal ganglia and poorly involvement of brainstem and hypothalamus are CT findings of rabies encephalitis. [3]
MRI imaging reveals ill-defined T2W-hyperintense areas involving the brainstem, predominantly the pontine tegmentum, dorsal aspect of the medulla, central white matter of the midbrain, periaqueductal gray matter, hippocampi, collicular plate, medial aspects of the thalami and bilateral hypothalami [4]. Affected areas do not show restricted diffusion or post-contrast enhancement, differentiating it from other demyelinating encephalopathies and metabolic aetiology [5].
No definite treatment is available for rabies encephalitis, but management with rabies vaccine, infusion of anti-rabies immunoglobin, interferon-alpha and ketamine-therapy during the early course of infection hasproven to reduce mortality and morbidity. But no treatment has been successful in reducing mortality in the symptomatic patient [6].
MRI is the imaging of choice even though it does not have significant impact on patient prognosis, MRI helps to differentiate rabies from other encephalitis and better public health outcome. MRI findings are useful for evaluating the course and pathology of the disease neuronal infection.
Written informed patient consent for publication has been obtained.
[1] Rao AS, Varma DR, Chalapathi Rao MV, Mohandas S. Case report: Magnetic resonance imaging in rabies encephalitis. Indian J Radiol Imaging. 2009;19:301–4. (PMID: 19881109)
[2] Tirawatnpong S, Hemachudha T, Manutsathit S, Shuangshoti S, Phanthumchinda K, Phanuphak P. Regional distribution of rabies viral antigen in central nervous system of human encephalitic and paralytic rabies. J Neurol Sci 1989;92(1):91–99.
[3] Awasthi M, Parmar H, Patankar T, Castillo M. Imaging findings in rabies encephalitis. AJNR Am J Neuroradiol. 2001;22:677–80. (PMID: 11290477)
[4] Laothamatas J, Hemachudha T, Mitrabhakdi E, Wannakrairot P, Tulayadaechanont S. MR Imaging in Human Rabies. AJNR Am J Neuroradiol. 2003;24:1102–9. (PMID: 12812933)
[5] Rao AS, Varma DR, Chalapathi Rao MV, Mohandas S. Case report: magnetic resonance imaging in rabies encephalitis. Indian J Radiol Imaging 2009;19(4):301–304.
[6] Hattwick MA, Weis TT, Stechschulte CJ, Baer GM, Gregg MB. Recovery from rabies: a case report. Ann Intern Med 1972;76(6):931–942.
URL: | https://www.eurorad.org/case/16610 |
DOI: | 10.35100/eurorad/case.16610 |
ISSN: | 1563-4086 |
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.