Interventional radiology
Case TypeClinical Cases
AuthorsK. Schürmann, K. Chalabi, J. Tacke, RW Günther, D. Vorwerk
Patient49 years, male
Eleven years later the patient suffered a TIA. A transoesophageal ultrasound was performed that showed, as an accidental finding, an aneurysm in the caudal segment of the descending thoracic aorta. The patient, who had no symptoms related to the aneurysm, was referred to our hospital for further treatment.
A CT scan was performed. The aneurysm, of a maximum axial diameter of 6 cm, had penetrated into the 11th and 12th thoracic vertebrae, and extended into the spinal canal (Fig. 1). Because of the previous cardiovascular surgery, the risk of open surgery was highly increased. Endovascular treatment was proposed to the patient as a less risky, but also less-established, option. Endovascular prostheses with large diameters appropriate for the thoracic aorta were not yet commercially obtainable at that time. The Corvita prosthesis (formerly from the Corvita Company, now Boston Scientific, Brussels, Belgium) was available in suitable diameters, but that was still in the stage of clinical evaluation. The Corvita prosthesis is a stent-graft with an outer Elgiloy wiremesh covering an inner lining with the synthetic polymer polyurethane carbonate [1]. The prosthesis is manually cut to the required length and preloaded into a dedicated delivery device.
The pros and cons of both treatment options were discussed with the patient in detail. The patient preferred the endovascular approach. The coumarin medication was changed to heparin and intra-arterial angiography was performed to assess the local vascular anatomy (Fig. 2).
Follow-up CT scans were done the day after the intervention, and in 2–4 month intervals during the next 1.5 years (Fig. 3). The CT scan after 7 months demonstrated a narrowing of more than 50% of the aortic lumen in the mid-segment caused by progressive caudal expansion and cranial constriction of the caudal stent-graft (Fig. 4).
In a second intervention 1 month later, a 3 cm long Palmaz stent premounted on a 25 mm balloon was successfully placed in the stenotic segment. The stenosis was completely removed (Fig. 4), and the aneurysm remained excluded. However, the follow-up CT scan 17 months after the first intervention revealed reperfusion of the aneurysm in the caudal segment (Fig. 5a). The findings remained stable during the next 17 months (Fig. 5b and 5c). Reperfusion probably resulted from progressive shortening of the caudal stent-graft. No futher interventions have been undertaken. Fifty-four months after the first treatment the patient is alive and well.
Aortic aneurysm formation indicating tertiary syphilis is very rare nowadays. Consequently, there are only a few case reports in the literature, but no reports on larger series [2]. The 5- and 10-year survival rate of patients with untreated thoracic aneurysms is about 50% and 30%, respectively [3]. Endoluminal repair of thoracic aorta aneuryms is not yet an established method of treatment, and is usually confined to patients with an increased risk of open surgery. In a recent review article the overall aneurysmal thrombosis rate after endoluminal treatment was reported to be 90–100% [4]. The postoperative mortality rate was said to be 0–4%, and the rate of paraplegia 0–1.6%. These figures are much better than those reported in a larger series of 103 patients with endoluminal repair of thoracic aortic aneurysms published by Mitchell and co-workers in 1999 [5]. In this series patients were treated between 1992 and 1997 with homemade stent-grafts. The average follow-up time was 22 months. The overall aneurysmal thrombosis rate was 83% and perioperative mortality was 9%. Major perioperative morbidity occurred in 31 patients and included paraplegia in 3, and cerebrovascular accident in 7. Only 53% of patients were free of treatment failure at 3.7 years. The authors attributed the high mortality and morbidity rates to the severe comorbidities of the patients, and predicted that second-generation devices, in combination with increasing experience, would lead to better results in the future.
[1]
Dereume JP, Ferreira J, Dehon P, Cavenaile JC, Le Minh T, Motte S, Guyot S, Wautrecht JC.
Treatment of abdominal aortic aneurysm by application of a Corvita endoprosthesis. Medium-term results of a feasibility study.
Chirurgie 1996; 121(6):428-31. (PMID: 8978136)
[2]
Mickley V, Mohr W, Orend KH, Sunder-Plassmann L.
Aneurysm of the descending thoracic aorta in tertiary syphilis.
Vasa 1995;24(1):72-6. (PMID: 7725781)
[3]
Bickerstaff L, Pairolero P, Hollier L, Melton LJ, Van Peenen HJ, Cherry KJ, Joyce JW, Lie JT.
Thoracic aortic aneurysms: A population-based study.
Surgery 1982 Dec; 92:1103-1108. (PMID: 7725781)
[4]
Dake MD.
Endovascular stent-graft management of thoracic aortic diseases.
Eur J Radiol 2001 Jul;39(1):42-49. (PMID: 11439230)
[5]
Mitchell RS, Miller DC, Dake MD, Semba CP, Moore KA, Sakai T.
Thoracic aortic aneurysm repair with an endovascular stent graft: the "first generation".
Ann Thorac Surg 1999 Jun;67(6):1971-1974. (PMID: 10391350)
URL: | https://www.eurorad.org/case/1224 |
DOI: | 10.1594/EURORAD/CASE.1224 |
ISSN: | 1563-4086 |