Cervicofacial actinomycosis occurs infrequently, but represents the most common site of involvement of this disease, accounting for 50% of cases [1, 2]. It generally affects immunocompromised patients and oral mucosa breakdown is the main risk factor, as a result of trauma, dental extraction or poor dental hygiene [1–3]. Oral endogenous Actinomyces species are the causative agents, with Actinomyces israelli being the most common pathogen implicated [1, 2, 4]. The perimandibular area is predominantly involved, but cheek, parotid gland, teeth and tongue are also common locations . Cervicofacial actinomycosis primarily affects the soft-tissue. However, osteomyelitis of the underlying bone, though rare, may also occur by direct extension or haematogeneous spread, and mainly affects the mandible . Imaging findings are not specific, but are essential to evaluate local extent and to define treatment planning [1, 5]. The infection usually spreads contiguously, crossing fascial planes; nevertheless, localized forms have also been described [4–6]. CT usually depicts an infiltrative soft-tissue mass with relative homogeneous contrast enhancement and surrounding inflammatory changes . A central core of suppurative necrosis may be found in some cases, but large necrotic or cystic areas are rarely seen . Abscess and spontaneous fistula formation generally occur in acute and sub-acute phases [2, 4, 5]. Osteomyelitis imaging findings also depend on the activity of the disease; areas of osteolysis are predominant in the acute phase, while sequester formation, predominance of sclerosis and periosteal reaction occur in chronic forms [3, 5]. Regional lymphadenopathies may occur later in 40% of cases [1, 5]. Nonetheless, lymphatic spread is not typical of this disease, in opposition to malignant tumours and chronic granulomatous infections (mainly tuberculosis and nocardiosis), which represent the main differential diagnosis. The diagnosis requires the identification of Actinomyces isolated from pathological specimens; these are Gram-positive bacteria that produce filamentous branching hyphae and form asexual spores. However, the high rate of false-negative cultures and the variable presence of sulphur granules, only identified in 35-55% of cases but highly specific for this disease, may pose a diagnostic problem [1, 2]. Early and prolonged antibiotic treatment is critical to preclude extensive local destruction, but resection of necrotic tissue, fistulectomy and abscess drainage may also be necessary [1, 5]. In conclusion, cervicofacial actinomycosis still remains a challenging disease and a high index of suspicion is necessary to provide an early diagnosis. Although soft-tissue involvement is the preferential manifestation of this disease, extensive bone involvement can also occur, as exemplified by this case.