CASE 1039 Published on 12.07.2001

Congenital cytomegalovirus infection and hydrocephalus



Case Type

Clinical Cases


R.N.Sener, F.Tercan, E.Erginöz, A.O.Evlice, O.Yalman


20 days, male

No Area of Interest ; Imaging Technique CT
Clinical History
Retarded motor development, and macrocephaly.
Imaging Findings
The patient presented with severely retarded motor development, and an enlarged head. Hepatosplenomegaly was noted. Serologic tests for CMV infection were positive in the child and mother. A CT study was performed.
CMV is the most common cause of congenital infection caused by a DNA virus belonging to the herpesvirus group. The condition occurs by transplacental virus transmission. In the early gestation CMV infection can cause neuronal migrational anomalies, and later infections can cause encephaloclastic disorders such as subependymal paraventricular cysts, hydranencephaly, micrencephaly. Hydrocephalus is commonly seen. It is important to differentiate severe hydrocephalus from hydranencephaly. A shunting procedure is usually effective for reexpansion of the brain mantle in severe hydrocephalus. If this is ineffective the condition is in favor of hydranencephaly. On the other hand, presence of an intact falx excludes a lobar holoprosencephaly, another entity in the differential diagnosis of severe hydrocephalus.
Differential Diagnosis List
CMV infection and hydrocephalus
Final Diagnosis
CMV infection and hydrocephalus
Case information
DOI: 10.1594/EURORAD/CASE.1039
ISSN: 1563-4086