EURORAD ESR

Case 14919

Krabbe disease in a 6-month old male presenting with neurodevelopmental regression and psychomotor delay: A case report

Author(s)
Gerard G. Viterbo, MD
Ryan Jason DL. Urgel, MD, DPBR

Philippine General Hospital;
Taft Avenue,
Ermita Manila
1000 Manila, Philippines
 
Patient
male, 6 month(s)
 
 
  • Figure 1
    Axial T1-weighted MRI
     

    At the high frontal and parietal lobes showing cerebral volume loss as evidenced by the prominence of the subarachnoid spaces.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;

    At the level of the basal ganglia, across the temporal lobes, showing cerebral volume loss as evidenced by the prominence of the subarachnoid spaces.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;

    At the cerebellar hemispheres showing cerebral volume loss as evidenced by the prominence of the subarachnoid spaces.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;
     
     
  • Figure 2
    Coronal T2-weighted MRI

    At the level of the hippocampi showing no abnormal signals or volume loss within the said structure. Evaluation of the entire limbic system was likewise unremarkable.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;
     
     
  • Figure 3
    Axial T2-weighted MRI
     

    At the level of the corona radiata showing white matter hyperintensities.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;

    At the level of the basal ganglia showing white matter hyperintensities.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;

    At the level of the corona radiata showing no enhancement in the contrast-enhanced images.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;

    At the level of the basal ganglia showing no enhancement in the contrast-enhanced images. Note the well-defined cystic lesions in the posterior limb of both internal capsules.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;
     
     
  • Figure 4
    Axial T2-weighted and FLAIR MRI
     

    Abnormal bright signals in the cerebral peduncles. These regions, along with the involved portions of the supratentorial brain, point to involvement of the corticospinal tract.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;

    Abnormal bright signals in the cerebral peduncles. These regions, along with the involved portions of the supratentorial brain, point to involvement of the corticospinal tract.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;

    Abnormal bright signals in the medulla and cerebellar hemispheres. These regions, along with the involved portions of the supratentorial brain, point to involvement of the corticospinal tract.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;

    Abnormal bright signals in the medulla and cerebellar hemispheres. These regions, along with the involved portions of the supratentorial brain, point to involvement of the corticospinal tract.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;
     
     
  • Figure 5
    Axial T2-weighted MRI

    At the level of the basal ganglia showing relative hypointensity of the thalami. No lesions suggestive of gray-matter heterotopia is detected in the rest of the white matter.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Contrast agent-intravenous; Special Focus: Metabolic disorders;
     
     
At the high frontal and parietal lobes showing cerebral volume loss as evidenced by the prominence of the subarachnoid spaces.
 
At the level of the basal ganglia, across the temporal lobes, showing cerebral volume loss as evidenced by the prominence of the subarachnoid spaces.
 
At the cerebellar hemispheres showing cerebral volume loss as evidenced by the prominence of the subarachnoid spaces.
 
At the level of the hippocampi showing no abnormal signals or volume loss within the said structure. Evaluation of the entire limbic system was likewise unremarkable.
 
At the level of the corona radiata showing white matter hyperintensities.
 
At the level of the basal ganglia showing white matter hyperintensities.
 
At the level of the corona radiata showing no enhancement in the contrast-enhanced images.
 
At the level of the basal ganglia showing no enhancement in the contrast-enhanced images. Note the well-defined cystic lesions in the posterior limb of both internal capsules.
 
Abnormal bright signals in the cerebral peduncles. These regions, along with the involved portions of the supratentorial brain, point to involvement of the corticospinal tract.
 
Abnormal bright signals in the cerebral peduncles. These regions, along with the involved portions of the supratentorial brain, point to involvement of the corticospinal tract.
 
Abnormal bright signals in the medulla and cerebellar hemispheres. These regions, along with the involved portions of the supratentorial brain, point to involvement of the corticospinal tract.
 
Abnormal bright signals in the medulla and cerebellar hemispheres. These regions, along with the involved portions of the supratentorial brain, point to involvement of the corticospinal tract.
 
At the level of the basal ganglia showing relative hypointensity of the thalami. No lesions suggestive of gray-matter heterotopia is detected in the rest of the white matter.
 
 
 
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