EURORAD ESR

Case 14482

Transient splenial lesion of corpus callosum associated with discontinuation of antiepileptic therapy

Author(s)
Dr. Monika Nukala, Dr. Paul Joy, Dr. Ganesh. K, Dr. Jini Abraham

AJ Hospital and Resarch Centre,
AJ Institute of Medical Sciences;
Kuntikana 575004, Mangaluru, India;
Email:drmonikanukala@gmail.com
 
Patient
female, 17 year(s)
 
 
  • Figure 1
    First MRI done on 30/12/2016

    Axial T2 weighted image shows evidence of well-defined oval altered signal intensity area in the splenium of corpus callosum.

     
    Area of Interest: Head and neck; Imaging Technique: MR; Procedure: Imaging sequences; Special Focus: Seizure disorders;
     
     
  • Figure 2
    Diffusion images taken on 30/12/16
     

    Axial diffusion-weighted image showing a well-defined oval lesion in the centre of the splenium of the corpus callosum.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Imaging sequences; Special Focus: Seizure disorders;

    ADC maps shows diffusion restriction in the splenium of the corpus callosum.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Imaging sequences; Special Focus: Seizure disorders;
     
     
  • Figure 3
    MRI done on 4/01/2017

    Axial FLAIR images taken 5 days after treatment with phenytoin shows there is mild reduction in hyperintensity in the splenium of the corpus callosum.

     
    Area of Interest: Head and neck; Imaging Technique: MR; Procedure: Imaging sequences; Special Focus: Seizure disorders;
     
     
  • Figure 4
    MRI done on 12/01/2017
     

    T2 weighted axial image taken 13 days after starting treatment with antiepileptic drug showing significant decrease in the signal intensity.

     
    Area of Interest: Head and neck; Imaging Technique: MR; Procedure: Imaging sequences; Special Focus: Seizure disorders;

    Axial diffusion-weighted image shows decrease in the signal intensity in the splenium of the corpus callosum.

     
    Area of Interest: Neuroradiology brain; Imaging Technique: MR; Procedure: Imaging sequences; Special Focus: Seizure disorders;

    ADC images reveal reversal of diffusion restriction 13 days after antiepileptic therapy.

     
    Area of Interest: Head and neck; Imaging Technique: MR; Procedure: Imaging sequences; Special Focus: Seizure disorders;
     
     
Axial T2 weighted image shows evidence of well-defined oval altered signal intensity area in the splenium of corpus callosum.
 
Axial diffusion-weighted image showing a well-defined oval lesion in the centre of the splenium of the corpus callosum.
 
ADC maps shows diffusion restriction in the splenium of the corpus callosum.
 
Axial FLAIR images taken 5 days after treatment with phenytoin shows there is mild reduction in hyperintensity in the splenium of the corpus callosum.
 
T2 weighted axial image taken 13 days after starting treatment with antiepileptic drug showing significant decrease in the signal intensity.
 
Axial diffusion-weighted image shows decrease in the signal intensity in the splenium of the corpus callosum.
 
ADC images reveal reversal of diffusion restriction 13 days after antiepileptic therapy.
 
 
 
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