EURORAD ESR

Case 14430

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH); a case of multiple pulmonary nodules

Author(s)
Dr Nicky Dineen, Dr Natasha Davendralingam, Dr Alastair Ironside, Dr Stephen Ellis

St Bartholomews' Hospital,
Barts NHS Trust,
Radiology;
West Smithfield,
EC1A 7BE, London
Corresponding Author: nicky.dineen@bartshealth.nhs.uk
 
Patient
female, 76 year(s)
 
 
  • Figure 1
    Radiology: Axial CT chest
     

    Axial CT chest demonstrating multiple nodules affecting all lobes of the lung, particularly the lower lobes.

     
    Area of Interest: Thorax; Imaging Technique: CT-High Resolution; Procedure: Imaging sequences; Special Focus: Endocrine disorders;

    Axial CT chest demonstrating multiple nodules affecting all lobes of the lung, particularly the lower lobes.

     
    Area of Interest: Thorax; Imaging Technique: CT-High Resolution; Procedure: Imaging sequences; Special Focus: Endocrine disorders;

    Axial CT chest demonstrating multiple nodules affecting all lobes of the lung, particularly the lower lobes.

     
    Area of Interest: Thorax; Imaging Technique: CT-High Resolution; Procedure: Imaging sequences; Special Focus: Endocrine disorders;
     
     
  • Figure 2
    Radiology: Coronal CT chest

    Coronal CT chest demonstrating mosaicism.

     
    Area of Interest: Thorax; Imaging Technique: CT-High Resolution; Procedure: Imaging sequences; Special Focus: Endocrine disorders;
     
     
  • Figure 3
    Pathology Slides 1

    Image 1: Haematoxylin and Eosin (H&E) stained section of lung tissue showing a fibrotic focus with associated neuroendocrine cell hyperplasia (black arrows). (x4 objective)

     
    Area of Interest: Thorax; Imaging Technique: CT-High Resolution; Procedure: Biopsy; Special Focus: Endocrine disorders;
     
     
  • Figure 4
    Pathology Slides 2

    Image 2: H&E stained section of a neuroendocrine cell nest. The cells have granular nuclear chromatin (black arrows) and eosinophilic cytoplasm (red arrows). (x40 objective)

     
    Area of Interest: Thorax; Imaging Technique: CT-High Resolution; Procedure: Biopsy; Special Focus: Endocrine disorders;
     
     
  • Figure 5
    Pathology Slides 3

    Neuroendocrine cells showing strong diffuse positive (brown) membranous staining of neuroendocrine marker CD56 (x20 objective).

     
    Area of Interest: Thorax; Imaging Technique: CT-High Resolution; Procedure: Biopsy; Special Focus: Endocrine disorders;
     
     
Axial CT chest demonstrating multiple nodules affecting all lobes of the lung, particularly the lower lobes.
 
Axial CT chest demonstrating multiple nodules affecting all lobes of the lung, particularly the lower lobes.
 
Axial CT chest demonstrating multiple nodules affecting all lobes of the lung, particularly the lower lobes.
 
Coronal CT chest demonstrating mosaicism.
 
Image 1: Haematoxylin and Eosin (H&E) stained section of lung tissue showing a fibrotic focus with associated neuroendocrine cell hyperplasia (black arrows). (x4 objective)
 
Image 2: H&E stained section of a neuroendocrine cell nest. The cells have granular nuclear chromatin (black arrows) and eosinophilic cytoplasm (red arrows). (x40 objective)
 
Neuroendocrine cells showing strong diffuse positive (brown) membranous staining of neuroendocrine marker CD56 (x20 objective).
 
 
 
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