Head & neck imaging
Case TypeClinical Cases
Authors
Rita Cruz1,2, Ana Primitivo1
Patient68 years, female
A 68-year-old woman with multinodular thyroid disease and normal thyroid function was referred for an ultrasound. A dominant nodule was detected in the right lobe. US-guided fine-needle aspiration cytology (FNAC) was performed and categorised as a lesion of undetermined significance twice, with the third FNAC suggestive of a branchial cleft cyst.
US showed a predominantly solid heterogeneous nodule with hyperechogenic areas and a well-defined slightly irregular hypoechoic contour. There were no visible calcifications nor hypervascularisation on Doppler examination. The caudal part of the nodule was of limited evaluation.
After the third FNAC result, the patient was referred for a surgical consultation. For anatomic preoperative evaluation, CT of the neck was requested and depicted a well-circumscribed nodule occupying the posterior and inferior portion of the right thyroid lobe, causing contralateral deviation of the trachea and oesophagus. The lesion had soft-tissue density, calcifications and macroscopic fat.
At this point, a teratoma was suspected.
Thyroid teratoma is an exceptionally rare neoplasia that can mimic multinodular disease of the thyroid. Due to its rarity, the clinical features and natural history of the disease are largely unknown.
Most are diagnosed in newborns and infants and display benign features, while the majority of the cases reported in adults are malignant [1-3].
Teratomas are congenital tumours arising from ectopic primordial germ cells that fail to migrate to the gonads during the first weeks of embryogenesis. Accordingly, they occur along the midline and paramidline in both gonadal and extragonadal sites [4]. By definition, they contain elements of all three germ-cell layers [1, 3, 5].
Cervical teratomas are considered to be of thyroid origin if at least one of the following criteria are met: the teratoma occupies part of the gland, it is in direct continuity with the gland, or there is a complete absence of the thyroid. The latter hypothesises that there might have been total replacement of the thyroid by the tumour or, alternatively, that the teratoma originated from a thyroid precursor that failed to develop into a mature gland [1, 5].
Fine-needle aspiration cytology is often indeterminate and diagnostic imaging tests are not enough to differentiate malignant tumours from benign, therefore surgical resection is required for final diagnosis and treatment [1-3, 5, 6].
Presentation is as a neck nodule. Depending on the size of the lesion, they can cause airway or oesophageal compression, much like multinodular goitre [1, 3].
By definition teratomas are heterogeneous, thus may contain a wide range of tissues with different imaging characteristics. US may show a predominantly solid nodule with cystic components, typically with a well-defined hypoechoic margin. Coarse calcifications and hyperechogenic components related to the presence of fat can be identified. The CT features are similar to those described in other locations. In general CT depicts a well-demarcated heterogeneous solid lesion with varied attenuations of fluid, soft-tissue, fat and calcium [3, 5]. Like their mediastinal counterparts, large lesions tend to displace other structures.
Our patient underwent surgical resection via right hemithyroidectomy and a diagnosis of benign cystic teratoma of the thyroid was made based on the surgical specimen evaluation.
TEACHING POINTS
A thyroid teratoma is an exceedingly rare lesion in adults and its preoperative diagnosis by FNAC is challenging.
Cross-sectional imaging may help when fat and calcifications are detected.
The majority of cases in adults are malignant and definitive diagnosis is only possible after pathologic analysis. As such, surgical resection is required.
Written informed patient consent for publication has been obtained.
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[4] De Felici M (2013) Origin, Migration, and Proliferation of Human Primordial Germ Cells. In: Coticchio G, Albertini DF, De Santis L, eds. Oogenesis. Springer
[5] Riedlinger WF, Lack EE, Robson CD, Rahbar R, Nose V (2005) Primary thyroid teratomas in children: a report of 11 cases with a proposal of criteria for their diagnosis. Am J Surg Pathol 29:700-6 (PMID: 15832097)
[6] Nishihara E, Miyauchi A, Hirokawa M, Kudo T, Ohye H, Ito M et al (2006) Benign thyroid teratomas manifest painful cystic and solid composite nodules: three case reports and a review of the literature. Endocrine 30:231-6 (PMID: 17322585)
URL: | https://www.eurorad.org/case/16713 |
DOI: | 10.35100/eurorad/case.16713 |
ISSN: | 1563-4086 |
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